Phylogenetic position of three sumatran medical plants predicted with anticancer activity and their relations to withania somnifera based on internal transcribed species region

5/27/2018 12:00:00 AM

---

Authors:Agustina DR Nurcahyanti, Topik Hidayat

Publication date: 20 Mei 2018

Journal of Pharmacy Research

Volume:  Vol 12, Issue 5, 711-716

Link: http://jprsolutions.info/files/final-file-5b078ec28497d0.00051793.pdf

 

 

Aims: Many naturally occurring molecules have shown promising anticancer activity; however, common drug-resistant issues and undesirable side effects have constrained those applications. Thus, new anticancer drugs and drug combination strategies from nature are highly required. Molecular phylogenetic analysis has been considered as a first step of discovering new natural bioactive compounds.

Materials and Methods: Phylogenetic tree reconstruction based on DNA sequence of internal transcribed species (ITS) of three medicinal plants from Sumatra which are Tetracera, Rhodamnia, and Flemingia was performed in the current study. Some ITS sequences of other species, especially anticancer plant Ashwagandha (Withania somnifera) collected from GenBank were included in the analysis.

Results: Parsimony tree showed that Rhodamnia and Flemingia species are closely related to Ashwagandha, indicating the potencies of Rhodamnia and Flemingia from Sumatra as anticancer agents.

Conclusion: Further, investigations in relation with in vitro, in silico, and in vivo analyses are highly required. Mechanism of action of those plants, especially as anticancer is described.

 

KEY WORDS: Anticancer, Flemingia, Mechanism of action, Rhodamnia, Sumatra, Withania somnifera