Oral Squamous Cell Carcinoma Positive fo HPV Genotypes 16 and 18: A Retrospective Clinicopathologic Study in Yogyakarta, Indonesia

5/29/2018 12:00:00 AM

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Authors:Isadora Gracia, Irianiwati, Totok Utoro, Supriatno, Indwiani Astuti, Didik Setyo Heriyanto, Dibyo Pramono

Publication date: 27 May 2018

Journal of International Dental and Medical Research

Volume:  11(3): 866-871

Link: http://www.jidmr.com/journal/wp-content/uploads/2019/01/18_D18_651_Isadora_Gracia.pdf

 

Abstract

Human papillomavirus (HPV) is closely related with the incidence of OSCC. Few studies conducted in Indonesia have focused on the association of HPV genotypes with OSCC. In this study, the prevalence of HPV infection and correlate it with the clinicopathologic features of OSCC patients was investigated.

This retrospective study involved 64 FFPE blocks which diagnosed as OSCC in the year of 2011–2015. DNA extraction was conducted with a commercial kit. HPV-positive samples were genotyped using a commercial kit. Bivariate analysis was conducted to correlate clinicopathologic features with HPV genotypes.

Thirty-five out of 64 (54.7%) OSCC samples were positive for HPV. Of these cases, eight (22.86%) and 3 (8.57%) cases were positive for HPV genotypes 18 and 16, respectively. HPV infection was found in 23 out of 38 (60.50%) male patients and 22 out of 36 (61.10%) female patients aged ≥55 years old. HPV DNA was detected in 22 out of 37 (59.5%) tongue samples and in 28 out of 49 (57.1%) samples with well-differentiated histopathologic features.

Results suggested that 54.7% of OSCC patients were HPV infected. The tongue was the most common  anatomical  site  for  HPV-positive  OSCC.  The  prevalence  of  well-differentiated  HPV- positive OSCC was 57.1%.

 

Keywords: OSCC, HPV genotype 16 and 18, Clinicopathologic.