Antibiotic Susceptibility Patterns of Salmonella Typhi in Jakarta and its Trends Within the Past Decade

12/16/2018 12:00:00 AM

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Authors:Lucky H Moehario, T Robertus, Enty Tjoa, Wani D Gunardi, Angela Ch M Nusatia, Daniel Edbert

Publication date: 15 December 2018

Journal of Biological Sciences

Volume:  19 (1); 40-45

Link: https://scialert.net/fulltextmobile/?doi=jbs.2019.40.45

 

 

Abstract

Background and Objective: A trend of changing susceptibility of Salmonella Typhi, the etiologic agent of typhoid fever to antibiotics, especially the first line occurred elsewhere to the worst, in which emerged the multiple drug resistance strains. This study aimed to investigate the susceptibility of Salmonella Typhi isolates from hospitalised patients in Jakarta and its satellite city to the 1st line antibiotics and others and evaluated whether there is a change of the pattern in the past decade.

Materials and Methods: The study was a retrospective analysis. Records of antibiotic susceptibility of Salmonella Typhi  from 2012-2017 in the hospitals in North, Central and West Jakarta and the satellite city, i.e., South Tangerang was retrieved from WHONET (5.4 and 5.6 version). Antibiotic susceptibility of 80% or greater was determined as good activity in vitro . The susceptibility of Salmonella Typhi  in 2008-2010 from hospitals in Central and West Jakarta was also included to view its trend within a decade period.

Results: Susceptibility of Salmonella Typhi isolates to the 1st line antibiotics i.e., Amoxicillin, Ampicillin, Chloramphenicol, Trimethoprim-sulfamethoxazole was good, also to Ceftriaxone, Nalidixic acid, Ciprofloxacin, Levofloxacin. The pattern relatively remained unchanged for the past 10 years towards most of the antibiotics tested.

Conclusion: Susceptibility of Salmonella Typhi  from Jakarta and the satellite city was good to the 1st line antibiotics and others within a decade period. Hence, these can be of choice for the treatment of typhoid fever, especially when microbiology laboratory diagnostic is not available.

 

Key words: Salmonella typhi, first line antibiotics, satellite city, hospitalised patients, antibiotic susceptibility