Glial cells involvement in pathogenesis of human immunodeficiency virus-associated sensory neuropathy (HIV-SN): literature review

6/10/2019 12:00:00 AM

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Authors:I Putu Eka Widyadharma, Jimmy Barus, Putri Rossyana Dewi, Faldi Yaputra, I Made Oka Adnyana, DPG Purwa Samatra

Publication date: May 31, 2018

International Journal of Medical Reviews and Case Reports

Volume:  -

Link:https://www.researchgate.net/profile/Eka_Widyadharma/publication/325602120_Glial_Cells_Involvement_in_Pathogenesis_of_Human_I

 

ABSTRACT Human Immunodeficiency Virus (HIV) infection has become an epidemic all around the world especially in developing countries including Indonesia. AIDS has so many comorbidities, and complications, one of them  is HIV associated sensory neuropathy (HIV-SN).  Distal  sensory polyneuropathy (DSP) and  toxic antiretroviral neuropathy (ATN) are the most  common HIV-SN, disorders that  characterised by peripheral nerve  damage. These disorders have the same  feature which is “dying back”,  a mechanism in which the long  axon  in the distal region degenerates. This mechanism is worsened by macrophages infiltration and loss of unmyelinated fibres in peripheral nerve and dorsal  root ganglion (DRG). In recent  studies, the pathogenesis of HIV-SN  showed the involvement of glial cells (microglia and astrocyte). In this review,  we will focus on the involvement of glial cells in the pathogenesis of HIV-SN.

 

KEYWORDS HIV Sensory  Neuropathy, Glial Cells, Antiretroviral Toxic Neuropathy