Biomarker potential of IQ-domain GTPase-activating proteins family protein in pancreatic cancer: A mini review

4/4/2018 12:00:00 AM

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Authors:Anton Sumarpo, Agnes Anania Triavika Sahamastuti, Gidella Edny Tjugianto, Kenny Yonathan, David Agustriawan

Publication date: 25 March 2018

Asian Journal of pharmaceutical and Clinical Research

Volume:  Vol 11, Special Issue 3

Link: https://innovareacademics.in/journals/index.php/ajpcr/article/view/30021

 

 

Objectives: Our present study was done to understand molecular regulatory mechanisms of IQGAP proteins and their potentials as biomarker in pancreatic cancer.

 

Methods: In this review, relevant studies were obtained by assessing the PubMed database using the

combination of words that included “IQGAP” and “pancreatic cancer”.

 

Results: There is an increasing evidence showing that the expression of IQGAP1 and IQGAP3 is positively correlated with tumorigenesis; however, IQGAP2 might play a role to suppress tumor progression.

 

Conclusion: IQGAP proteins might have potentials as predictive and prognostic biomarker for human pancreatic cancer.

 

Keywords: Pancreatic cancer, IQ-domain GTPase-activating proteins, Tumor biomarker, Early detection, Prognostic value.