The Role Of 5-Lipoxygenase In Pathophysiology And Management Of Neuropathic Pain

9/4/2018 12:00:00 AM

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Authors:Pascanus Lamsihar, Faldi Yaputra, Jimmy Barus, I Putu Eka Widyadharma

Publication date: 29 Agustus 2018

International Journal of Medical Reviews and Case Rerports

Volume:  2 (3); 58-61

Link: https://www.ejmanager.com/fulltextpdf.php?mno=2428

 

 

ABSTRACT Neuropathic pain (NP) is a pain caused by lesions in the nervous system.  Several causes of NP are traumatic, metabolic disorders, ischemia, toxins,  infections, immune-related, and  hereditary. The pathophysiology of NP is very complicated and  unknown entirely. Therefore the treatment of NP is still unsatisfactory. Recent  studies believed the critical  role  of primary inflammatory mediators in the  pathophysiology of NP  especially leukotrienes (LTs).  The 5- lipoxygenase enzyme  (5-LOX) is an enzyme  that plays a role in the metabolism of arachidonic acid into LTs. Leukotrienes (LTs) are the essential inflammatory mediators in the pathophysiology of NP. Leukotriene B4 (LTB4) can cause chemotaxis on neutrophils, lowering nociceptors threshold and may contribute to NP. Several studies believed  the administration of 5-LOX inhibitors or LTs receptor antagonists could be useful  in the management of NP. The purpose of this review  is to summarize the involvement of 5-LOX enzyme as an essential role in the pathophysiology and management of NP.

 

KEYWORDS 5-lipoxygenase, leukotrienes, pathophysiology of neuropathic pain, inflammatory mediators, management of neuropathic pain