The prognostic value of S100A10 expression in cancer (review)

11/28/2018 12:00:00 AM

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Authors:Normastuti Adhini Tantyo, Azrina Saraswati Karyadi, Siti Zulimas Rasman, Marvelmario Reginald Gabriel Salim, Astrella Devina, Anton Sumarpo

Publication date: November 23, 2018

Oncology Letters

Volume:  -

Link:https://www.researchgate.net/publication/329154990_The_prognostic_value_of_S100A10_expression_in_cancer_Review

 

 

Abstract.    SlOOAlO,   a  member  of  the  S100 protein family, commonly forms  a  heterotetrarneric       complex    with   Annexin A2. This  is essential   for  the generation   of cellular   plasmin   from plasminogen,     which   leads   to  a  cascade    of  molecular     events crucial   for  tumor   progression.    SlOOAI0  upregulation  has  been reported    in  a number   of  cancers,   suggesting    that  it may  have potential     as  a  prognostic  biomarker, as  well   as  predicting sensitivity to  anticancer drugs.  This    review    evaluates the direct  and  indirect    relationships    between   SlOOAlO  and  cancer progression    by investigating    its role in cancer.   Research   papers published   on PubMed   and  Google   Scholar   between   2007-2017 were   coUated    and   reviewed.     We  concluded      that   S100AI0 affects  the development    of the hallmarks    of cancer   as explained by Hanahan   and  Weinberg   in 2011, most  notably   by activating the  invasion   and  metastasis    of  cancer   cells.   However,   further studies    are   required     to  explore    the   underlying      biological mechanisms    of SIOOAlO.

 

Key  words:  SlOOAIO. cancer,  cancer   progression,   hallmarks   of cancer, biomarker