Authors:Wanitphakdeedecha R, Iamphonrat T, Phothong W, Eimpunth S, Inneke Jane Hidajat, Manuskiatti W
Publication date: 2018 Jun 29
J Cosmet Dermatol
Volume: -
Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12691
Summary
Background: Epidermal growth factor (EGF) is one of the important peptides in wound healing process. The effects of EGF have been increasingly studied in various types of ulcers. However, data on postablative laser resurfacing wound is still lim- ited.
Objectives: To evaluate the effects of the topical EGF ointment on wound healing process and postinflammatory hyperpigmentation (PIH) prevention after fractional ablative laser resurfacing.
Materials and methods: This is a randomized split-face study. Nineteen healthy sub- jects were enrolled and completed follow up protocol. Patients received single treat- ment of fractional carbon dioxide laser on both cheeks. After randomization, each patient was assigned to apply one side of the face with topical EGF ointment and another side with petrolatum. Wound healing was evaluated by duration of scab shedding, duration of postlaser erythema, erythema index, and transepidermal water loss on the daily follow up period of seven days after treatment. PIH was evaluated at 2, 3 weeks and 1, 2 months follow up by photographs and melanin index.
Results: Most of patients were female with Fitzpatrick skin phototype III to V. Com- paring with control (petrolatum), EGF treated side showed no significant difference in duration of scab shedding, duration of postlaser erythema, erythema index, and transepidermal water loss (P-value = .58, .22, .78, and .51, respectively). Incidence of PIH was 52.6% on EGF side and 57.9% on petrolatum side, however, it was not statis- tically different (P = .56). The melanin index was also not different as well (P = .96). Conclusion: Topical EGF might provide significant wound healing stimulation for chronic wound more than acute wound. Further studies, especially in post laser wound or other cosmetic purposes are needed.
KEYWORDS
epidermal growth factor, fractional laser resurfacing, postinflammatory hyperpigmentation, postlaser erythema, skin barrier function, wound healing
Results: Most ofpatientswere femalewithFitzpatrick skinphototypeIIItoV.Com- paringwithcontrol (petrolatum), EGFtreatedsideshowednosignificantdifferencein duration of scab shedding, duration of postlaser erythema,erythema index, and transepidermalwater loss(P-value=.58,.22,.78,and.51,respectively). Incidence of PIHwas52.6%onEGFsideand57.9%onpetrolatumside,however, itwasnotstatis- ticallydifferent(P=.56).Themelaninindexwasalsonotdifferentaswell(P=.96). Conclusion: Topical EGF might provide significant wound healing stimulation for chronic wound more than acute wound. Further studies, especially in post laser wound orother cosmetic purposesareneeded.
KEYWORDS
epidermal growth factor, fractional laserresurfacing, postinflammatoryhyperpigmentation, postlasererythema,skinbarrier function, wound healing