The Effect Of Jobs Tears Enriched Yogurt On GLP 1, Calprotectin, Blood, Glucose Levels and Weight Of Patients With Type 2 Diabetes Mellitus

3/1/2019 12:00:00 AM

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Authors: Nanny Djaja, Inge Permadi, Fiastuti Witjaksono, Pradana Soewondo, Moerdani Abdullah, Rina Agustina, Soegianto Ali

Publication date: February 2019

Mediterranean Journal of Nutrition and Metabolism

Volume:, 12, 163-171

Link:  https://app.dimensions.ai/details/publication/pub.1112321955

 

Abstract :

BACKGROUND: Involving    natural   food   ingredients    in  controlling blood glucose    in  diabetic patients has  been   widely studied.  However,   there  is little  information    about  the  effect  of  the  ingredients on  improvement     of clinical,   laboratory,    and gut function   markers.

OBJECTIVE: This  study  was  aimed  to examine   the effect  of Job‘s  tears-enriched    yoghurt   on weight,   fasting  blood  glucose, GLP-I,   and Calprotectin    in patients   with  type  2 Diabetes   Mellitus.

METHODS:  Sixty  male  and  female   subjects   with  T2DM   participating    in  this  study  were  divided   in two  groups;   received yoghurt  (control  group/C)   and Job‘s   tears-enriched     yoghurt   (treatment   group lT).   Subjects   use  metformin   only  were  allowed. Job‘s   tears  seed  was   extracted  using a standard  process.:  Height   and  weight   were  measured.  Laboratory    examination     for fasting  blood  glucose,   GLP-I,   and  calprotectin    were  performed   using  standard   methods.   Appropiate    statistical   analysis   tests were  applied  to examine   variables   change   within   and between   groups.   Significancy    was  set  at p < 0.05.

RESULTS:    Characteristics     between   groups   were  comparable.    Weight  and FBG  reduced   significantly    in bothgroups    (weight in  C;  64.5  vs  63.5  kg,  p=O.Ol;   FBG   in  C;  130.7  vs  128.7  mgldL,   p=0.04,    weight   in  T,  64.8  vs  63.1  kg,  p=O.Ol,   FBG in  T;  129.2  vs  110.8  mgldL,  p=0.03)    with  greater   reduced   in T group  (weight; -1.01   vs  -1.68  kg, p=0.02,   FBG;  -1.30   vs -18.1  mgldL,  p < 0.0 I). Calprotectin     decreased    significantly    in T group (36.1  vs 23.4  ug/g,  P = 0.02)  but   change   was  not significant   different   with  C group.

CONCLUSION:  Adding   Job‘s   tear  could  enhance   the effect  of yoghurt   in reducing   weight   and  FBG  in T2DM   patients.

Keywords:   Job‘s  tear,  yoghurt,   diabetes,   natural   ingredients,    gut inflammation    marker