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The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split-face randomized controlled study

Authors:Wanitphakdeedecha R, Iamphonrat T, Phothong W, Eimpunth S, Inneke Jane Hidajat, Manuskiatti W

Publication date: 2018 Jun 29

J Cosmet Dermatol

Volume:  -

Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12691

 

Summary

Background: Epidermal  growth   factor   (EGF) is  one  of  the   important  peptides  in wound  healing process.  The effects  of EGF have been  increasingly studied  in various types  of  ulcers.  However,  data  on  postablative laser  resurfacing  wound  is still lim- ited.

Objectives:  To evaluate  the  effects  of the  topical  EGF ointment on  wound  healing process   and  postinflammatory hyperpigmentation  (PIH) prevention after  fractional ablative  laser resurfacing.

Materials and methods:  This is a randomized split-face  study.  Nineteen healthy  sub- jects  were  enrolled  and completed follow up protocol.  Patients received  single treat- ment  of  fractional  carbon  dioxide  laser  on  both  cheeks.  After  randomization, each patient was  assigned  to  apply  one  side  of the  face  with  topical  EGF ointment and another side  with  petrolatum. Wound   healing  was  evaluated by  duration   of  scab shedding,  duration  of postlaser erythema, erythema index, and transepidermal water loss on the  daily follow up period  of seven  days after  treatment. PIH was evaluated at 2, 3 weeks  and 1, 2 months  follow up by photographs and melanin index.

Results:  Most  of patients were  female with Fitzpatrick  skin phototype III to V. Com- paring with control  (petrolatum),  EGF treated side showed no significant difference in duration   of  scab  shedding,   duration   of  postlaser  erythema, erythema  index,  and transepidermal water  loss (P-value = .58, .22, .78, and .51, respectively).  Incidence  of PIH was 52.6% on EGF side and 57.9% on petrolatum side, however,  it was not statis- tically different (P = .56). The melanin index was also not different as well (P = .96). Conclusion:  Topical  EGF  might  provide   significant  wound   healing  stimulation   for chronic  wound   more  than   acute   wound.   Further   studies,   especially  in  post   laser wound  or other  cosmetic  purposes are needed.

 

KEYWORDS

epidermal  growth  factor,  fractional  laser resurfacing,  postinflammatory hyperpigmentation, postlaser erythema, skin barrier  function,  wound  healing

Results:  Most  ofpatientswere  femalewithFitzpatrick  skinphototypeIIItoV.Com- paringwithcontrol  (petrolatum),  EGFtreatedsideshowednosignificantdifferencein duration   of  scab  shedding,   duration   of  postlaser  erythema,erythema  index,  and transepidermalwater  loss(P-value=.58,.22,.78,and.51,respectively).  Incidence  of PIHwas52.6%onEGFsideand57.9%onpetrolatumside,however,  itwasnotstatis- ticallydifferent(P=.56).Themelaninindexwasalsonotdifferentaswell(P=.96). Conclusion:  Topical  EGF  might  provide   significant  wound   healing  stimulation   for chronic  wound   more  than   acute   wound.   Further   studies,   especially  in  post   laser wound  orother  cosmetic  purposesareneeded.

 

KEYWORDS

epidermal  growth  factor,  fractional  laserresurfacing,  postinflammatoryhyperpigmentation, postlasererythema,skinbarrier  function,  wound  healing

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